Coumarin-based 1,3,4-oxadiazoline ring is well acknowledged to possess significant anticancer and antimicrobial activities. In an attempt to find more effective and selective chemotherapeutic agents against cancer and microbial infections, a series of 7-((4-acetyl-5-(substituted phenyl)-4,5-dihydro-1,3,4-oxadiazolin-2-yl)methoxy)-4-methyl-2H-chromen-2-one [IIa-e] were synthesized by heterocyclization of coumarin Schiff bases Ia-e and characterised by IR, NMR and mass spectral data. The title compounds were evaluated for in-vitro anticancer activity at different concentrations against non-small lung cancer cell line A549 by MTT assay, in-vitro antitubercular activity against M. Tuberculosis H37Rv strain in DMSO by almar blue method and antibacterial activity against Gram positive bacteria S. aureus and Gram negative bacteria E. coli by serial dilution method; 5-flurouracil, streptomycin and ciprofloxacin were used as standard drugs respectively. Among the synthesized compounds, IIe with 1,2-dioxymethlyene group on phenyl ring showed maximum anticancer and antitubercular activity. However, all the compounds exhibited feeble activity when compared to standard drugs used in the study, warranting further study.
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